Copper and Zinc Complexes Reactivity Data for Cancer Cell Lines and Biomolecules

A dataset containing experimental results for copper(II) and zinc(II) complexes with imine ligands derived from oxindole and benzimidazole scaffolds. The data includes IC50 values for cytotoxicity against cervical HeLa and melanoma SK-Mel cell lines, results from DNA interaction studies, and measurements of reactive oxygen species generation. It was authored by Aline Monteiro L. Zaballa and last updated on May 7, 2026.

Use Cases

• Compare cytotoxicity of copper vs. zinc complexes based on IC50 values for HeLa and SK-Mel cell lines.
• Analyze DNA binding mechanisms based on descriptions of groove binding and strand cleavage.
• Investigate reactive oxygen species (ROS) profiles based on measurements of singlet oxygen, hydrogen peroxide, superoxide, and hydroxyl radicals.
• Study structure-activity relationships based on the presence of oxindole and benzimidazole scaffolds in the ligands.

Strengths

• IC50 values for cancerous cell lines are reported in the range of a few μM.
• Data includes results from multiple analytical techniques: elemental analyses, UV/Vis, FTIR, EPR, Raman spectroscopies, and ESI-MS.
• Interactions with multiple biomolecular targets are described, including DNA, human serum albumin (HSA), and phosphatidylcholine liposomes.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (1.2 MB), suggesting limited scope or number of data points.

Provenance

Source

figshare

Collection Method

Experimental data from laboratory synthesis and biological assays.

Freshness

Last updated 2026-05-07 05:42:32; freshness should be verified.