Data Sheet 1_Comparative transcriptomic profiling of human conjunctival epithelial cells a

A transcriptomic study from 2026 by Ehsan Ghasemian, profiling responses at 4 and 24 hours post-infection. It contains RNA sequencing data on human conjunctival epithelial cells and macrophages infected with ocular Chlamydia trachomatis genovars A and B. The dataset includes differential gene expression and pathway enrichment analyses, revealing strain- and cell type-specific signatures.

Use Cases

• Identify strain-specific host transcriptional signatures based on comparisons between genovars A/2497 and B/Tunis864.
• Analyze temporal dynamics of infection based on data collected at 4 and 24 hours post-infection.
• Compare cell type-specific immune responses based on transcriptomes from conjunctival epithelial cells versus macrophages.
• Investigate interferon-stimulated gene pathway activation based on signatures highlighted in the description.

Strengths

• Includes data for two distinct ocular Chlamydia trachomatis genovars (A/2497 and B/Tunis864).
• Provides transcriptomic profiles at two time points (4 and 24 hours post-infection) for temporal analysis.
• Compares responses across two relevant human cell types (conjunctival epithelial cells and macrophages).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document (8.5 MB), which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

RNA sequencing and differential gene expression analysis performed on infected cell cultures.

Time Range

Data points at 4 and 24 hours post-infection.

Freshness

Last updated 2026-04-22 05:45:57; freshness should be verified.

Geography

null