Mouse Retinal Ganglion Cell Survival Data After MCT2 Knockout and Ocular Hypertension

Data Sheet 1_Compensatory transporter upregulation facilitates retinal ganglion cell survival in glaucoma after MCT2 elimination.docx contains research data from Kudakwashe P. Murinda, uploaded to figshare on 2026-04-29. The dataset likely contains measurements from an in vivo study investigating the necessity of monocarboxylate transporter-2 (MCT2) for retinal ganglion cell survival under ocular hypertension.

Use Cases

• Analyze compensatory metabolic transporter upregulation based on the mention of MCT1, MCT4, and GLUT3 changes.
• Evaluate retinal ganglion cell density and function preservation based on pattern electroretinogram amplitude and cell count data.
• Assess the protective effect of nicotinamide intervention based on the oral administration test described.
• Model metabolic adaptation in neurodegenerative conditions based on the described compensatory mechanisms after transporter knockout.

Strengths

• Data is associated with a specific experimental protocol involving an inducible conditional knockout mouse model.
• The study tests a defined intervention (oral nicotinamide at 500 mg/kg/day).
• The dataset is licensed under CC-BY-4.0, allowing for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 7.6 MB DOCX document, which may require extraction or conversion for analysis.

Provenance

Source

Kudakwashe P. Murinda

Collection Method

Likely contains experimental data from an in vivo study using an inducible conditional knockout mouse model and ocular hypertension induction.

Freshness

Last updated 2026-04-29 05:57:10; freshness should be verified.