Mouse Caudoputamen 3D Atlas of SST, PV, and TH Interneuron Distributions

A three-dimensional atlas mapping the spatial distribution of genetically-defined somatostatin (SST), parvalbumin (PV), and tyrosine hydroxylase (TH) GABAergic interneurons across the mouse dorsal striatum (caudoputamen). The dataset was created by Jonibek M. Muhsinov using genetic labeling, caudoputamen-wide imaging, and voxel-wise quantification, and was last updated in April 2026. It reveals distinct spatial gradients, such as SST and TH enrichment in ventral regions and PV enrichment in dorsal and posterior areas.

Use Cases

• Analyze spatial gradients of interneuron subtypes based on the described mediolateral, dorsoventral, and anteroposterior axes.
• Model region-specific inhibitory constraints on circuit computation based on the differential distribution patterns.
• Integrate interneuron organization into existing anatomical frameworks for linking striatal anatomy to function.
• Investigate potential sex differences in interneuron distribution based on the mention of statistically significant findings.

Strengths

• Provides a comprehensive 3D atlas of three key interneuron populations (SST, PV, TH) across the entire mouse caudoputamen.
• Quantifies opposing anteroposterior distribution patterns for PV and TH interneurons, a specific finding from the research.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analyses.
• The primary data file is a 3.5 MB DOCX document, which may not be a standard structured data format.

Provenance

Source

Jonibek M. Muhsinov, published on figshare.

Collection Method

Generated using genetic labeling, caudoputamen-wide imaging, and voxel-wise quantification.

Time Range

null

Freshness

Last updated 2026-04-16 04:20:30; freshness should be verified.

Geography

Mouse brain (caudoputamen/dorsal striatum).