BRCA1/2 Mutation Landscape in Prostate Cancer from UAE and Arab Patients

A retrospective analysis of BRCA1 and BRCA2 mutations in 40 archived prostate tissue samples from the United Arab Emirates and Arab population, collected between 2011 and 2022. The dataset, authored by Zainab M. Al Shareef and shared under a CC-BY-4.0 license, reports mutation prevalence, zygosity, and associations with tumor grade. It was last updated on 2026-05-26.

Use Cases

• Assess the prevalence of BRCA1/2 mutations in prostate cancer based on the reported 47.5% and 55% occurrence rates.
• Investigate the association between homozygous mutations and aggressive disease phenotypes based on the enrichment in high-grade tumors.
• Identify novel population-specific genetic variants based on the description of novel variants clustered in DNA repair domains.
• Evaluate the potential for ethnicity-informed genetic screening protocols based on the findings specific to UAE and Arab men.

Strengths

• Includes 40 patient samples with detailed mutation analysis.
• Reports specific mutation frequencies: BRCA1 mutations in 47.5% of cases, BRCA2 mutations in 55%.
• Identifies novel variants and their clustering in functional protein domains like the BRCA1 coiled-coil region.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale (927.3 KB), indicating limited scope.

Provenance

Source

Zainab M. Al Shareef

Collection Method

Retrospective analysis of archived formalin-fixed, paraffin-embedded prostate tissues with targeted exon sequencing.

Time Range

2011–2022

Freshness

Last updated 2026-05-26 05:25:51; freshness should be verified.

Geography

United Arab Emirates and Arab population