ART Effects on Alveolar Macrophages: Single-Nucleus Transcriptomic and Epigenetic Analysis

A research article analyzing the long-term impact of continuous antiretroviral therapy on alveolar macrophages in people with HIV and on PrEP. The study uses a systems immunology approach, including single-nucleus transcriptomic and epigenetic data, to characterize a progressive senescence-like state. The work was authored by Vinicius M. Fava and last updated in April 2026.

Use Cases

• Study the link between ART duration and cellular senescence based on transcriptomic and epigenetic priming data
• Analyze gene regulatory networks in alveolar macrophages based on single-nucleus sequencing results
• Investigate the impact of ART on interferon signaling and antiviral response based on ex vivo SARS-CoV-2 challenge data
• Model the progression of ART-induced dysregulation independent of HIV infection status

Strengths

• Data is associated with a detailed research article providing biological context and interpretation.
• The dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.
• The study design includes comparisons across HIV infection and PrEP status.

Limitations

• The primary data format is a PDF (4.6 MB), which may require extraction of underlying data tables or figures.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

A systems immunology approach evaluating alveolar macrophages from study participants, likely involving single-nucleus RNA sequencing and epigenetic assays.

Freshness

Last updated 2026-04-22 05:49:09; freshness should be verified.