Mouse Corneal Response to PM10 Exposure and Pseudomonas Infection

Sharon A. McClellan's dataset contains results from a study on the impact of whole-body PM10 exposure on corneal health in BALB/c mice. The data includes measurements of corneal sensitivity, tear production, Langerhans cell counts, bacterial plate counts, and mRNA levels for proinflammatory cytokines. The dataset was last updated on 2026-05-01.

Use Cases

• Modeling the relationship between PM10 exposure and corneal sensitivity changes based on reported measurements.
• Analyzing the protective effects of SKQ1 treatment on disease severity scores and bacterial counts.
• Investigating gene expression patterns for cytokines like glutathione peroxidase 4 and Nrf2 in response to pollutant exposure.
• Correlating immune cell populations (macrophages, T cells) quantified via flow cytometry with clinical infection outcomes.

Strengths

• Dataset includes multiple biological endpoints: clinical scores, bacterial counts, mRNA levels, and flow cytometry data.
• Experimental design includes control, PM10-exposed, and SKQ1-treated groups for comparative analysis.
• License is CC-BY-4.0, allowing for broad reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained within a 738.0 KB PDF file, which is a tiny dataset and may require extraction to a structured format.

Provenance

Source

figshare

Collection Method

Data originates from a controlled laboratory study involving mouse exposure, infection, and subsequent molecular and clinical assays.

Freshness

Last updated 2026-05-01 05:28:00; freshness should be verified.