Meta-Analysis of Staphylococcus Aureus Colonization and Atopic Dermatitis Severity

A 2025 systematic review and meta-analysis synthesizing data from seven randomized controlled trials with 929 participants. The analysis, conducted by Ruyi Jin, found a moderate positive correlation (r = 0.42) between Staphylococcus aureus colonization and atopic dermatitis severity. The results are derived from a random-effects model applied to correlation coefficients extracted from the included studies.

Use Cases

• Validate the association between bacterial colonization and disease severity based on the reported pooled correlation coefficient.
• Inform the design of future clinical trials for atopic dermatitis treatments based on the systematic review's findings.
• Benchmark new observational studies against the established meta-analytic effect size (r = 0.42).
• Conduct sensitivity or subgroup analyses on meta-analytic data as described in the document's methodology.

Strengths

• Includes data from 7 randomized controlled trials and 929 participants, providing a substantive sample for meta-analysis.
• Reports a specific pooled correlation coefficient (r = 0.42) with a 95% confidence interval (0.31–0.52).
• Employs a documented systematic review methodology with registration on PROSPERO (CRD420251104116).
• Conducts sensitivity and subgroup analyses, which the description indicates support the robustness of the main findings.

Limitations

• The underlying raw data (columns, rows) is not provided; the file contains only the review's analysis and results.
• Row count for the source studies is unknown, which may limit suitability assessment for secondary data analysis.
• The document format (DOCX) is less amenable to direct computational analysis compared to structured data formats.

Provenance

Source

Ruyi Jin via figshare.

Collection Method

Systematic review and meta-analysis of randomized controlled trials from PubMed, Embase, Cochrane Library, and Web of Science.

Time Range

Literature search up to July 19, 2025.

Freshness

Last updated 2026-05-07.