Immunogenetic and Computational Study of Pemphigus Vulgaris in a Turkish Cohort

A 2026 study by Bayram Toraman investigates HLA-DRB1 allele associations in 86 Turkish pemphigus vulgaris patients and 200 healthy controls. It integrates genetic association data with in silico analyses, including MHC peptide-binding prediction and molecular dynamics simulations, to explore a vector-derived cadherin mimicry hypothesis. The dataset is a 324.7 KB document containing the full study text and results.

Use Cases

• Analyzing HLA-DRB1 allele and genotype associations based on patient and control cohort data
• Evaluating structural similarity between vector-derived and desmoglein peptides based on in silico modeling results
• Testing the vector-derived cadherin mimicry hypothesis based on integrated genetic and computational findings

Strengths

• Includes data from 86 patients and 200 controls, providing a case-control cohort
• Integrates multiple computational methods: MHC peptide-binding prediction, AlphaFold modeling, and GROMACS simulations
• Released under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The 324.7 KB size indicates a limited textual document, not a large-scale dataset

Provenance

Source

figshare

Collection Method

PCR-SSOP and Luminex-based genotyping for HLA-DRB1 alleles, followed by computational modeling

Time Range

Study published in 2026

Freshness

Last updated 2026-03-17 13:06:41

Geography

Turkish patient and control cohorts