Shanghai MASLD Patient Mortality Study with Creatinine Clearance Rate

A research paper from figshare by Yingqi Hou analyzes a five-year cohort of 8,828 adults with Metabolic dysfunction-associated steatotic liver disease (MASLD) from Pudong District, Shanghai. The study evaluates the predictive value of creatinine clearance rate (CCR) for all-cause and cardiovascular mortality using Kaplan–Meier, LASSO, and Cox regression models.

Use Cases

• Analyze the association between creatinine clearance rate (CCR) tertiles and all-cause mortality risk using Cox proportional hazards models.
• Investigate the non-linear correlation between CCR and cardiovascular mortality via restricted cubic splines (RCS) analysis.
• Compare survival probabilities across CCR tertile groups using Kaplan–Meier curves and log-rank tests.
• Build a multivariate prognostic model for MASLD patients incorporating CCR as selected by LASSO regression.

Strengths

• Study cohort contains 8,828 MASLD patient records.
• Analysis spans a five-year longitudinal observation period.
• Employs multiple statistical methods: Kaplan–Meier, LASSO, Cox models, and RCS.

Limitations

• Dataset scope is limited to a single PDF document of 44.5 KB, containing summarized results, not the underlying patient-level data.
• Geographic focus is restricted to Pudong District, Shanghai, China, limiting generalizability.
• The actual tabular patient data with columns and rows is not provided or available for direct analysis.

Provenance

Source

figshare, author Yingqi Hou.

Collection Method

Five-year cohort study of adults with MASLD from Pudong District, Shanghai; analysis used Kaplan–Meier, LASSO, Cox models.

Time Range

Five-year cohort study (specific years not stated).

Freshness

Last updated March 2026.

Geography

Pudong District, Shanghai, China.