Data Sheet 1: Research on CRH Neurons in the AM-ACC Circuit for Pain-Anxiety Comorbidity

A 95.8 KB PDF research data sheet authored by Qingzan Zhao, last updated April 10, 2026. The document details findings on the role of corticotropin-releasing hormone (CRH) neurons in the anterior cingulate cortex (ACC) and their regulation by the anteromedial thalamic nucleus (AM) in chronic pain and anxiety comorbidity.

Use Cases

• Validate neural circuit models for pain-anxiety comorbidity based on the described AM-ACC pathway.
• Inform computational modeling of stress responses based on the role of corticotropin-releasing hormone (CRH) neurons.
• Guide experimental design for optogenetic or chemogenetic manipulations in related neuroscience studies.

Strengths

• Data is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• The research is highly specific, focusing on a defined neural circuit (AM-CaMKIIɑ-ACC-CRH).

Limitations

• The dataset is a 95.8 KB PDF, indicating a very limited scope likely containing summary data or figures rather than raw experimental data.
• Row count and column-level documentation are absent; data structure and semantics must be inferred from the document.
• The description metadata is limited; actual data quality and completeness require manual inspection after download.

Provenance

Source

Qingzan Zhao via figshare.

Collection Method

Likely contains data from immunofluorescence staining, calcium imaging, neural circuit tracing, patch-clamp recording, and optogenetic/chemogenetic manipulations as described.

Time Range

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Freshness

Last updated 2026-04-10 05:58:46.

Geography

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