TRIM28 Ubiquitination and Antiviral Signaling Experimental Data

13.4 MB of experimental data from a study on TRIM28's role in suppressing antiviral immune responses. The dataset includes results from TRIM28 overexpression, knockdown, and domain deletion assays, as well as protein interaction and ubiquitination analyses. Author Ruihua Xin published the findings on figshare in March 2026.

Use Cases

• Analyze TRIM28 knockdown effects on type I IFN responses and RNA virus replication data
• Examine protein interaction data from co-immunoprecipitation assays for TRIM28 and MAVS
• Study ubiquitination events, specifically K48-linked polyubiquitination of MAVS, from in-cell assays
• Investigate nucleocytoplasmic trafficking patterns of TRIM28 triggered by viral infection

Strengths

• Data underpins a peer-reviewed biological mechanism published in 2026
• Includes results from both in vitro experiments and an in vivo AAV-mediated lung-specific model
• Examines specific protein domains (RBCC) and ubiquitination sites (MAVS Lys136, Lys461)

Limitations

• Small dataset at 13.4 MB, indicating limited raw data or processed results only
• Scope is narrowly focused on the TRIM28-MAVS molecular axis
• Experimental data format and structure within the ZIP file are unknown

Provenance

Source

Ruihua Xin via figshare

Collection Method

Laboratory experiments including confocal microscopy, co-immunoprecipitation, and in-cell ubiquitination assays

Freshness

Last updated March 2026