Cross-Bridge Model Quantification of Muscle Metabolites During Knee Extension Exercise

Model-based predictions of muscle metabolite alterations during all-out knee extension exercise, authored by John I. Hendry and updated in March 2026. It is a 813.5 KB document file focusing on the roles of inorganic phosphate (Pi) and protons (H+) in fatigue development.

Use Cases

• Analyze the predicted contributions of inorganic phosphate (Pi) and protons (H+) to force inhibition during all-out exercise.
• Validate computational model predictions of motor unit recruitment data against simulated muscle force generation.
• Study the synergistic effect of Pi and H+ accumulation on cross-bridge detachment and strongly bound state formation.

Strengths

• Model predictions quantify the individual contributions of Pi (~9%) and H+ (~31%) to force inhibition.
• The analysis includes a specific comparison of metabolite roles between all-out knee extension and constant-power plantar flexion exercises.
• Dataset is associated with a peer-reviewed computational modeling study of human skeletal muscle.

Limitations

• The dataset is a 813.5 KB document, indicating a limited scope of tabular or structured data for direct computational analysis.
• Data is derived from model simulations contextualized with human subject data, not direct experimental measurements.
• The specific row count, column structure, and sample data are unavailable for assessment.

Provenance

Source

John I. Hendry via figshare.

Collection Method

Computational model simulations contextualized with motor unit recruitment data from human subjects.

Freshness

Last updated March 2026.