NRP1 and Autophagy Gene Co-Expression Analysis Across Ten Solid Tumors

A review synthesizes data from TCGA, GTEx, and HADb to analyze NRP1 and autophagy-related gene interactions. It identifies significant upregulation of NRP1 in 10 solid tumor types and reveals co-expression relationships between NRP1 and 340 autophagy-related genes (ATGs). The analysis explores the prognostic value of specific co-expression patterns, such as those involving CXCR4 and HSPA5, in cancers like gastric cancer and glioblastoma.

Use Cases

• Analyze NRP1 expression levels across 10 solid tumor types using pan-cancer data from TCGA and GTEx
• Investigate co-expression patterns between NRP1 and 340 autophagy-related genes (ATGs) to identify regulatory networks
• Assess the prognostic significance of specific gene pairs like NRP1-CXCR4 or NRP1-HSPA5 in gastric cancer and glioblastoma patient cohorts
• Explore the theoretical basis for combination therapies targeting the NRP1-autophagy axis in the tumor immune microenvironment

Strengths

• Analysis integrates data from three authoritative genomic databases: TCGA, GTEx, and HADb
• Identifies co-expression relationships between NRP1 and 340 specific autophagy-related genes
• Focuses on 10 distinct solid tumor types for pan-cancer relevance
• Provides specific prognostic findings for gene pairs in gastric cancer and glioblastoma

Limitations

• The core data is presented as a review document (DOCX), not a structured, machine-readable dataset for direct analysis
• The 1019.5 KB file size indicates a text-heavy review, limiting the volume of raw, tabular data available
• Specific row counts, column definitions, and sample data for the underlying genomic analyses are not provided

Provenance

Source

Data synthesized from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) project, and Human Autophagy Database (HADb).

Collection Method

Literature review and secondary analysis of publicly available genomic and expression databases.

Freshness

Last updated March 2026.