CrpH Protein Data Supporting Heme-Copper Oxidoreductase Function in Bordetella Pertussis

Majda Hachmi published a 6.3 MB PDF research article on 2026-03-18, detailing the characterization of the CrpH protein in Bordetella pertussis. The study combines in vitro and in vivo experiments with transcriptomics to show CrpH's role in bacterial fitness and respiration via heme-copper oxidoreductases. The work defines a new subfamily of PepSY_TM proteins found in diverse bacterial species harboring HCO genes.

Use Cases

• Training models for protein family classification based on sequence similarity networks mentioned in the description.
• Analyzing gene expression patterns related to copper starvation and bacterial fitness from transcriptomic data referenced in the study.
• Studying the functional relationship between heme-binding motifs and oxidoreductase activity as described for the CrpH protein.
• Investigating synthetic genetic interactions in bacteria based on the double mutant phenotype (crpH-ccoG) described.

Strengths

• Data is associated with a specific, peer-reviewed research study combining multiple experimental approaches.
• The dataset is licensed under CC-BY-4.0, allowing for broad reuse and sharing.
• The file is 6.3 MB, making it a manageable download.

Limitations

• The primary data format is a PDF, which may require extraction or manual parsing for computational analysis.
• Row count and column-level documentation are absent; data structure must be inferred from the article.
• The dataset's scale is limited to the specific findings and analyses presented in the single research paper.

Provenance

Source

figshare, authored by Majda Hachmi.

Collection Method

Research data generated through in vitro and in vivo experiments, transcriptomics, and in silico analyses.

Freshness

Last updated 2026-03-18 06:42:27.