Data Sheet 1_Culture supernatants from human-derived commensal bacteria alleviate DNCB-ind

A research article describes the anti-inflammatory and barrier-restoring effects of bacterial culture supernatants on atopic dermatitis. The document details in vitro experiments with human keratinocytes and fibroblasts, and in vivo evaluation using a DNCB-induced mouse model. The work was authored by Jaeeun Sin and uploaded to figshare in May 2026.

Use Cases

• Investigate the anti-inflammatory effects of bacterial metabolites based on IL-6 and CCL17 suppression mentioned in the description
• Study epidermal barrier restoration based on filaggrin expression data
• Analyze neurotrophic factor modulation based on BDNF, GDNF, and NGF expression changes
• Examine signaling pathway inhibition based on p38 MAPK and JAK-STAT mechanisms

Strengths

• The dataset includes a detailed description of experimental methods for in vitro and in vivo models.
• Specific biological markers like IL-6, CCL17, BDNF, and filaggrin are identified as key measured outcomes.
• The data is shared under a CC-BY-4.0 license, permitting open reuse.

Limitations

• The primary data (e.g., numerical results, cell counts, expression levels) is not provided in a structured, machine-readable format; it is embedded within a 104.6 KB DOCX document.
• Column-level documentation is absent; field semantics must be inferred from the text.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Experimental research involving cell culture and a mouse model, as described in the document.

Freshness

Last updated 2026-05-01 05:27:42; freshness should be verified.