Porcine Tail-Biting Injury Trial Comparing Novel Ointment to Antibiotic

A controlled study of 14 pigs with Grade 4 tail-biting injuries compares a novel curcumin-berberine ointment against standard oxytetracycline therapy over 21 days. The dataset is a 7.0 MB PDF containing results from a translational porcine model authored by Paweł Biernat and published in April 2026. It reports primary outcomes like healing time and secondary metrics including thermographic temperatures and hematological parameters.

Use Cases

• Model healing_time reduction (9.57 vs 13.43 days) based on treatment_group and wound_score trajectories.
• Analyze the correlation between infrared_thermography temperature (37.2°C vs 39.9°C) and neutrophil_count normalization (14.54 to 8.79 x10^9/L) as inflammation biomarkers.
• Predict serum_haptoglobin endpoint levels (0.74 vs 1.86 mg/mL) from early treatment response and thermographic assessments.
• Compare local_tolerance outcomes, such as irritation_index (<0.5), between the novel ointment and antibiotic spray groups.

Strengths

• Provides detailed quantitative results for 14 subjects over a 21-day trial with daily wound scoring.
• Includes multiple validated outcome measures: Wilson wound scores (0-35), thermography, and two hematological parameters (neutrophils, haptoglobin).
• Clear statistical reporting with p-values (e.g., p=0.023 for healing time) and standard deviations for all key metrics.

Limitations

• Very small sample size of 14 animals (n=7 per treatment group), limiting statistical power for subgroup analysis.
• Data is locked in a 7.0 MB PDF report; no underlying raw tabular data or time-series records are provided.
• Geographic and model bias: data comes from a single study on Polish Large White pigs, which may not generalize to other species or wound etiologies.

Provenance

Source

Figshare, authored by Paweł Biernat.

Collection Method

Data originates from a controlled laboratory study with randomized treatment groups.

Time Range

Trial duration of 21 days; specific study years not provided.

Freshness

Last updated April 2026, representing recent preclinical research.

Geography

Study location not specified; subjects were Polish Large White pigs.