Experimental Neuromyelitis Optica Spectrum Disorder Data Sheet

A 2.8 MB research document details murine models of neuromyelitis optica spectrum disorder (NMOSD). Liang Wang authored this study, which investigates pathogenic contributions of aquaporin-4-specific Tfh and Th17 cells via adoptive transfer. The file was last updated on May 28, 2026.

Use Cases

• Validate transcriptomic findings based on bulk RNA sequencing results mentioned in the description
• Correlate histopathological features with clinical scores based on reported perivascular inflammation and demyelination
• Investigate chemokine involvement in neuroinflammation based on the upregulation of CXCL9
• Compare pathogenic roles of T-cell subsets based on the adoptive transfer of AQP4-reactive Tfh and Th17 cells

Strengths

• The study employs multiple validation methods, including flow cytometry, immunohistochemistry, and quantitative PCR.
• The document provides a detailed methodological description of murine model generation and analysis.
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single 2.8 MB document, limiting its scale for direct computational analysis.

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory experiments involving adoptive transfer of T-cells into mice, followed by tissue analysis.

Freshness

Last updated 2026-05-28 04:50:56; freshness should be verified.