Cytokine Preactivation and ADCC in Human NK Cells Against 3D Tumor Models

Data Sheet 1 contains research findings on cytokine-induced memory-like (CIML) natural killer (NK) cell activity against colorectal and lung cancer 3D tumor models. The dataset, authored by Ainara Lopez-Pardo and shared on figshare under CC-BY-4.0, was last updated on May 8, 2026. It is a 2.5 MB PDF document detailing experimental results on NK cell degranulation, cytokine production, cytotoxicity, and infiltration in spheroids and patient-derived organoids.

Use Cases

• Analyzing the efficacy of cytokine preactivation (IL-12/15/18) on NK cell effector functions based on experimental results described.
• Evaluating antibody-dependent cellular cytotoxicity (ADCC) enhancement with cetuximab in 3D tumor models based on the context-dependent findings.
• Comparing NK cell infiltration and distribution within tumor spheroids between pre-CIML and control cells based on the described observations.
• Benchmarking NK cell anti-tumor activity in clinically relevant 3D models (spheroids and organoids) based on the provided cytotoxicity and cytokine data.

Strengths

• The dataset is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.
• The research focuses on clinically relevant 3D tumor models (spheroids and patient-derived organoids) for colorectal and lung cancer.
• The document was last updated on May 8, 2026, indicating recent availability.

Limitations

• The dataset is a 2.5 MB PDF; the underlying numerical or tabular data is not directly accessible.
• Column-level documentation and sample data are unavailable, requiring manual extraction of information from the text.
• The row count and specific data structure are unknown, limiting suitability assessment for computational analysis.

Provenance

Source

Ainara Lopez-Pardo via figshare

Collection Method

Experimental research involving co-culture of human NK cells with 3D tumor models.

Time Range

The experimental time frame is not specified in the provided metadata.

Freshness

Last updated 2026-05-08 05:51:48

Geography

The geographic scope of the research is not specified in the provided metadata.