Electrophysiological Properties of Aged Rat Anterior Cingulate Cortex Neurons

Whole-cell patch-clamp recordings from layer 2/3 pyramidal neurons in the anterior cingulate cortex of 26-month-old and 6-month-old male Long-Evans rats. The dataset, authored by Taketoshi Sugimura and last updated in 2026, compares intrinsic membrane properties and firing characteristics between aged and young adult neurons. It includes measurements of resting membrane potential, input capacitance, resistance, action potential thresholds, amplitudes, and sustained firing capacity under different current stimulations.

Use Cases

• Modeling age-related changes in neuronal excitability based on intrinsic membrane property data.
• Analyzing the relationship between action potential characteristics and cognitive aging based on measured thresholds and amplitudes.
• Investigating the capacity for sustained firing in aged neurons using ramp and triangular current stimulation results.

Strengths

• Direct comparison of aged (26-month-old) and young adult (6-month-old) rat neurons provides a controlled study of aging.
• Includes specific electrophysiological measurements such as action potential thresholds, amplitudes, and slow afterhyperpolarization amplitudes.

Limitations

• Dataset size is 176.0 KB, indicating a very limited scope and likely small sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Taketoshi Sugimura via figshare

Collection Method

Whole-cell patch-clamp recordings in acute brain slices from male Long-Evans rats.

Freshness

Last updated 2026-05-11 05:24:54; freshness should be verified.