ESCC Survival and Progression Patterns for CRT with Immune Checkpoint Inhibitors

Zhongmei Lin's dataset compares survival and progression patterns for patients with locally advanced unresectable esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT) alone versus CRT combined with immune checkpoint inhibitors (ICIs). The data covers 67 patients in the CRT+ICIs group and 415 historical controls from Fujian Cancer Hospital between August 2019 and August 2024, analyzed after 1:3 propensity score matching. It includes metrics such as median overall survival (31.1 vs. 18.6 months), progression-free survival, and adverse event rates.

Use Cases

• Compare overall survival outcomes based on treatment regimen (CRT alone vs. CRT+ICIs).
• Analyze progression patterns (local-regional vs. distant) using the Fine-Gray competing risks model described.
• Identify independent prognostic factors for survival, such as M stage, lactate dehydrogenase-to-albumin ratio (LAR), and prognostic nutritional index (PNI).
• Assess the safety profile of combined therapy based on the reported rate of grade 3 or higher adverse events (38.7%).

Strengths

• Includes a direct comparison of two treatment cohorts with 1:3 propensity score matching to correct for baseline imbalances.
• Reports specific survival metrics, including a median overall survival of 31.1 months for the CRT+ICIs group versus 18.6 months for the control group.
• Identifies three independent prognostic factors (M stage, LAR, PNI) through multivariable analysis.
• Provides a quantified safety profile, noting 38.7% of patients experienced grade 3 or higher adverse events.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single institution (Fujian Cancer Hospital), which may reflect geographic or institutional bias.

Provenance

Source

Fujian Cancer Hospital

Collection Method

Retrospective review of patient records.

Time Range

August 2019 to August 2024

Freshness

Last updated 2026-05-28 05:58:15; freshness should be verified.

Geography

Fujian, China