Mouse Cancer Cachexia Study: Energy Balance and Gene Expression by Tumor Load

A study directly comparing tumor-bearing mice inoculated with Lewis-lung carcinoma at 1x10^6 cells versus 0.5x10^6 cells. Maria Licursi authored this dataset, which examines weight gain, adiposity, food efficiency, and hypothalamic gene expression. The findings suggest metabolic profiles vary with initial tumor load, complicating the relationship between systemic energy balance and cancer progression.

Use Cases

• Modeling the correlation between food efficiency and body weight gain based on tumor load groups
• Analyzing hypothalamic neuropeptide (Pomc, Agrp, Hcrt) mRNA expression changes in tumor-bearing mice
• Investigating the relationship between inflammatory genes (Ccl2, Il6) and neuropeptide expression in cachexia
• Comparing metabolic outcomes between high and low initial tumor cell inoculation groups

Strengths

• Dataset includes direct comparison of two distinct tumor load groups (TBhigh and TBlow).
• Analysis covers multiple physiological and molecular endpoints: weight gain, adiposity, food intake, and hypothalamic gene expression.
• License is CC-BY-4.0, permitting open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 920.7 KB DOCX file, likely containing processed results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Experimental study inoculating mice with Lewis-lung carcinoma cells and measuring physiological and molecular outcomes.

Freshness

Last updated 2026-05-19 04:19:01; freshness should be verified.