Data Sheet 1_Design, synthesis, and biological evaluation of derivatives from p-toluic hyd

Eighteen Schiff base derivatives were synthesized and evaluated for antibacterial properties. The dataset, authored by Yaguang Liu and last updated in May 2026, details the biological evaluation of lead compound C17, including MIC values, cytotoxicity, and pharmacokinetic profiling. It likely contains experimental results from assays measuring membrane depolarization, biofilm inhibition, and anti-inflammatory activity.

Use Cases

• Identify potential lead compounds based on reported minimum inhibitory concentration (MIC) values against Gram-positive bacteria.
• Assess compound safety profiles based on hemolytic activity and cytotoxicity data mentioned in the description.
• Study structure-activity relationships for Schiff base derivatives using the synthesized series of eighteen compounds.
• Evaluate pharmacokinetic properties for drug development based on reported plasma protein binding, lipophilicity, and metabolic stability.
• Investigate anti-biofilm and anti-inflammatory mechanisms based on described assays for biofilm inhibition/eradication and cytokine suppression.

Strengths

• Includes specific quantitative results, such as MIC values of 16–32 μg/mL for compound C17 and 89.3% plasma protein binding.
• Describes a multi-faceted evaluation covering antibacterial activity, mechanistic studies, biocompatibility, and pharmacokinetics.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data is contained within a 2.1 MB DOC file, which may require parsing to extract structured information.

Provenance

Source

figshare

Collection Method

Experimental research involving chemical synthesis and biological assays.

Freshness

Last updated 2026-05-14 05:30:54; freshness should be verified.