Data Sheet 1: Development of a Humanized Mouse Model for Sjögren's Syndrome

A research document describing the development of a humanized mouse model for Sjögren's syndrome. The study details methods for injecting patient PBMCs into NSG mice and evaluating therapeutic efficacy with metformin. The document was authored by Jin-Sil Park and last updated in May 2026.

Use Cases

• Understanding the development of preclinical animal models based on the described humanized murine platform.
• Analyzing immunopathological features of Sjögren's syndrome based on the described cellular infiltration and cytokine production.
• Evaluating therapeutic interventions for autoimmune diseases based on the described metformin treatment protocol.
• Studying the role of specific immune cell subsets like CXCR3+ Th17 cells based on their mentioned association with pathology.

Strengths

• The description provides a detailed methodological protocol, including specific cell counts (1 × 10^6 or 2 × 10^6 PBMCs) and timeframes (15-hour stimulation, 5-week administration).
• The document is licensed under CC-BY-4.0, allowing for open sharing and reuse.
• Results include specific pathological findings, such as reduced Aquaporin-5 expression and increased IL-17-producing T cells.

Limitations

• The dataset is a 110.8 KB DOCX file, suggesting limited scope and likely containing textual descriptions rather than raw experimental data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Likely contains a research manuscript detailing experimental methods.

Freshness

Last updated 2026-05-22 05:34:48; freshness should be verified.