Research Paper on Dicaffeoylquinic Acid Targeting PLA2G4B in Alcoholic Liver Disease

A 2026 research paper by Linlin Wang, published under a CC-BY-4.0 license on figshare, details a study on alcoholic liver disease (ALD). The paper investigates the protective effects of 4,5-Dicaffeoylquinic acid (DCA-C) using ethanol-induced mouse models and transcriptomic sequencing. It identifies PLA2G4B as a core target and describes the inhibition of the MAPK signaling pathway.

Use Cases

• Validate molecular docking predictions based on the identified PLA2G4B target.
• Analyze transcriptomic sequencing results from ethanol-induced mouse models.
• Study dose-response relationships in animal models based on DCA-C treatments at 10, 30, and 100 mg/kg.
• Investigate the AA-MAPK signaling pathway inhibition described in the results.
• Reproduce in vitro and in vivo validation experiments involving PLA2G4B overexpression.

Strengths

• The study includes dose-response data from three distinct DCA-C concentrations (10, 30, and 100 mg/kg).
• Mechanistic validation uses both in vitro and in vivo PLA2G4B overexpression models.
• The dataset is a full-text research paper providing detailed methodology and results.

Limitations

• The dataset is a single PDF document (612.8 KB); the underlying raw data (e.g., transcriptomic sequences, numerical results) is not provided separately.
• Column-level documentation is absent; any data tables within the PDF must be manually extracted and interpreted.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

Linlin Wang via figshare.

Collection Method

Research involving ethanol-induced ALD mouse models, transcriptomic sequencing, and molecular docking.

Freshness

Last updated 2026-05-29 04:49:10; freshness should be verified.