DKK2 Gene Expression and Evodiamine Binding in Acute Myeloid Leukemia

Gene expression data for Dickkopf 2 (DKK2) in acute myeloid leukemia (AML) sourced from the Gene Expression Omnibus and The Cancer Genome Atlas. The dataset includes results from cell-based assays and molecular docking simulations predicting the interaction between DKK2 and the compound evodiamine. The data was uploaded by Rui Li and last updated on April 30, 2026.

Use Cases

• Predicting patient survival based on DKK2 expression levels mentioned in the description
• Modeling drug-target interactions based on the reported binding affinity between evodiamine and DKK2
• Analyzing gene expression patterns associated with AML cell proliferation and apoptosis from described assays

Strengths

• Data is sourced from two authoritative public repositories, GEO and TCGA.
• Includes a specific molecular docking result with a binding energy of -5.51 kcal/mol.
• Released under a permissive CC-BY-4.0 license.

Limitations

• The dataset is described in a 1.1 MB DOCX file, which may not be a standard data format for direct analysis.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Gene Expression Omnibus (GSE26294) and The Cancer Genome Atlas (TCGA).

Collection Method

Data analysis from public repositories, combined with original cell-based assays (CCK-8, EdU staining, AO/EB staining, transwell) and computational molecular docking.

Freshness

Last updated 2026-04-30 05:28:51; freshness should be verified.