Murine Asthma Model Data on Fructooligosaccharides and Microbiome

Experimental data from a study investigating four doses of dietary fructooligosaccharides in a murine model of house dust mite-induced allergic asthma. The dataset includes measurements of bronchoalveolar lavage fluid, lung tissue, serum, cecum content, fecal microbiome composition, and short-chain fatty acid levels. It was authored by Roos E. M. Verstegen and published under a CC BY 4.0 license.

Use Cases

• Analyze correlations between fecal Prevotellaceae abundance and serum acetate concentrations to understand microbiome-metabolite links in allergic mice.
• Model the dose-dependent effect of FOS percentages on Th2 cell frequency and Th2/Th1 ratio in lung tissue.
• Examine relationships between cecal SCFA concentrations and pulmonary type 2 inflammation markers like CCL22 and IL-13 in BALF.
• Investigate microbial shifts, such as changes in Oscillospiraceae and Lactobacillaceae abundance, associated with different FOS diet doses.

Strengths

• Data captures four distinct FOS dose levels (1%, 2.5%, 5%, 10%) for dose-response analysis.
• Includes multi-faceted measurements from BALF, lung tissue, serum, cecum content, and fecal microbiome.
• Published under a permissive CC BY 4.0 license for open reuse.

Limitations

• Dataset is small at 2.5 MB, indicating limited sample size or scope.
• Data is contained in a DOCX file, which is not a standard structured format for quantitative analysis and may require manual extraction.
• Sample data and column structure are unavailable, complicating direct programmatic use.

Provenance

Source

Roos E. M. Verstegen via figshare

Collection Method

Data collected from a controlled murine experiment where BALB/c mice received FOS diets prior to and during HDM sensitization and challenges.

Time Range

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Freshness

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Geography

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