Clinical Study of Alzheimer's Disease and Periodontitis in 110 Patients

110 patients with mild cognitive impairment or dementia due to Alzheimer's disease were evaluated for oral hygiene, periodontitis status, and levels of gingipain and neuropathological biomarkers in cerebrospinal fluid. The study found periodontitis was more prevalent and severe in patients with dementia and that gingipain K levels correlated with Alzheimer's pathology. The dataset is a research document authored by Jing-hui Li and last updated in April 2026.

Use Cases

• Analyze correlations between periodontitis severity and cognitive impairment stages based on clinical symptom evaluations mentioned in the description
• Investigate the role of gingipain K in Alzheimer's pathology based on biomarker correlations described in the results
• Study the prevalence of periodontitis in different stages of Alzheimer's disease based on the reported patient group frequencies

Strengths

• Includes data from 110 patients across two distinct clinical stages of Alzheimer's disease
• Measures multiple biomarker types, including gingipain, β-amyloid, phosphorylated tau, and synaptosomal-associated protein 25
• Released under a permissive CC-BY-4.0 license for reuse

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• The dataset is a 77.7 KB DOCX file, indicating a very limited scope, likely a summary document rather than raw data

Provenance

Source

figshare

Collection Method

Clinical evaluation of oral hygiene, periodontitis status, and cerebrospinal fluid biomarkers in patient groups.

Time Range

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Freshness

Last updated 2026-04-20 05:19:29; freshness should be verified

Geography

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