Data Sheet 1_Differential efficacy and anti-inflammatory mechanisms of Bailing Preparation

A network meta-analysis of 18 randomized controlled trials involving 1,564 participants, comparing the efficacy of Bailing Preparations and Huangkui Capsules combined with SGLT-2 inhibitors for diabetic kidney disease. The dataset includes results on renal function, proteinuria, metabolic indicators, and anti-inflammatory markers, with evidence quality assessed using the GRADE method. It was authored by Xinyu Li and uploaded to figshare in May 2026.

Use Cases

• Compare treatment efficacy rankings for renal function protection based on serum creatinine (Scr) reduction and SUCRA values.
• Analyze differential impacts on proteinuria reduction based on 24-hour urine protein quantification results.
• Investigate anti-inflammatory mechanisms by comparing effects on systemic (TNF-α, CRP) versus local (IL-6) inflammatory markers.
• Assess relative safety profiles of adjunctive treatments using SUCRA probability rankings for adverse events.

Strengths

• Includes results from 18 randomized controlled trials, providing a multi-study evidence base.
• Reports specific quantitative outcomes, such as mean differences (MD) and 95% confidence intervals for key clinical indicators.
• Employs standardized assessment methods, including the Cochrane RoB 2.0 tool and GRADE evidence quality framework.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analytical tasks.
• The search period extends to December 2025, which is a future date relative to the upload, suggesting potential planned or ongoing study inclusion.

Provenance

Source

figshare, author Xinyu Li.

Collection Method

Computerized searches across nine biomedical databases (e.g., PubMed, Embase, CNKI), followed by network meta-analysis using Stata 19.5.

Time Range

From database inception to December 2025.

Freshness

Last updated 2026-05-29 06:07:43; freshness should be verified.

Geography

Likely global, but specific geographic coverage of included trials is not detailed.