Data Sheet 1_Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter

A 2026 study by Wei Wang investigates white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment (ANI). The dataset includes neuroimaging metrics from 47 ANI patients and 48 matched healthy controls, derived from diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI). It proposes a White Matter Dys-coupling Index (WDI) correlated with clinical and cognitive metrics.

Use Cases

• Train models to classify neurocognitive impairment based on fractional anisotropy (FA) and amplitude of low-frequency fluctuations (SWALFF) metrics.
• Analyze structure-function coupling patterns in white matter pathways based on overlapping FA-SWALFF alterations.
• Investigate the relationship between the proposed White Matter Dys-coupling Index (WDI) and clinical variables like infection duration.
• Study dynamic functional variability in white matter using the dSWALFF metric mentioned in the description.

Strengths

• Includes data from 95 subjects (47 patients, 48 controls), providing a matched cohort.
• Proposes a novel quantitative metric (WDI) with reported significant correlations to clinical and cognitive scores.
• Integrates multi-modal neuroimaging data (DTI and rs-fMRI) onto a unified white matter skeleton.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary file format is DOCX, which may require extraction or conversion for analysis.

Provenance

Source

Wei Wang via figshare

Collection Method

Neuroimaging data collected from enrolled patient and control groups, processed via a white matter skeleton-based fusion framework.

Time Range

Study published in 2026; specific data collection period is not stated.

Freshness

Last updated 2026-04-16 05:18:55; freshness should be verified.

Geography

Geographic coverage of the subject cohort is not specified.