Data Sheet 1_Direct oral anticoagulants in children with giant coronary artery aneurysms f

A systematic review and meta-analysis published in 2026, aggregating data from 594 pediatric patients across five studies to evaluate the efficacy and safety of direct oral anticoagulants (DOACs) versus conventional anticoagulation for Kawasaki disease-associated giant coronary artery aneurysms. The work was authored by Sze Kiat Alan Ong and is available as a document on figshare under a CC-BY-4.0 license. It includes pooled risk ratios for thromboembolic events and bleeding outcomes.

Use Cases

• Compare thromboembolic event rates between DOACs and conventional anticoagulation based on pooled risk ratios.
• Evaluate major bleeding risk profiles for different anticoagulant therapies based on reported event proportions.
• Assess the methodological rigor of pediatric anticoagulation studies based on the inclusion of randomized clinical trials and observational designs.
• Support clinical guideline development for Kawasaki disease management based on the conclusion of non-inferior efficacy and safety.

Strengths

• Includes data from 594 patients across five distinct studies, providing a substantial sample for meta-analysis.
• Incorporates results from two randomized clinical trials (RCTs), which are considered a high-quality study design.
• Reports specific statistical outcomes, including risk ratios (RR 0.27) and confidence intervals (95% CI: 0.02–3.17).
• Registered with PROSPERO (CRD420251004094), indicating adherence to systematic review protocols.

Limitations

• The dataset is a 786.7 KB document; the underlying data tables or raw patient-level data are not provided.
• Column-level documentation is absent; field semantics must be inferred from the text.
• Row count for the original studies is unknown, which may limit suitability assessment for direct data reuse.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed (MEDLINE), Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov.

Time Range

Studies from conception until October 2025.

Freshness

Last updated 2026-04-10 06:02:06