VAOTV-1: Novel Orthototivirus-Like Virus in Vulvovaginal Candidiasis Patients

A 2026 study by Ziyuan Dai identified a novel double-stranded RNA virus, Vaginal-associated orthototivirus-like 1 (VAOTV-1), in patients with vulvovaginal candidiasis. The dataset includes a partial genome sequence of 4,332 bp, encoding a complete RNA-dependent RNA polymerase and a partial capsid protein. The findings expand the known diversity of totiviruses in human-associated mucosal environments.

Use Cases

• Phylogenetic analysis based on the novel RdRp and capsid protein sequences to determine evolutionary relationships.
• Characterization of viral diversity in the vaginal microenvironment based on metagenomic sequencing data.
• Comparative genomics based on the 47.43% amino acid identity to known Totiviridae sequences.
• Investigation of virus-fungus-host interactions in vulvovaginal candidiasis based on the association with a fungal infection.

Strengths

• Includes a specific, novel viral genome sequence of 4,332 bp.
• Provides detailed phylogenetic and amino acid identity analysis (e.g., 47.43% identity to a known Totiviridae sequence).
• Released under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 2.7 MB PDF, which is a small file; underlying raw sequencing data is not directly provided.
• Column-level documentation and sample data are unavailable, requiring manual extraction from the PDF.
• The geographic and demographic scope of the patient samples is not specified.

Provenance

Source

Ziyuan Dai via figshare.

Collection Method

Viral metagenomic sequencing of vaginal swab samples using an Illumina NovaSeq platform.

Freshness

Last updated 2026-03-19 06:49:51.