Mouse Model Cardiac Data for Hereditary Sensory and Autonomic Neuropathy VI

A 607.1 KB PDF research article from 2026 investigates arrhythmia mechanisms in a conditional Dystonin gene-trap mouse model of Hereditary Sensory and Autonomic Neuropathy type VI. The study, authored by Nozomu Yoshioka, analyzes heart rate variability and pulse frequency under isoflurane anesthesia to explore the role of disrupted visceral afferent neural circuits. It was published on the figshare platform.

Use Cases

• Analyze the relationship between Dystonin gene inactivation in PNS neurons and increased heart rate variability.
• Compare cardiac rhythm dysregulation outcomes from Advillin-Cre versus Vglut2-Cre mediated Dst gene inactivation.
• Study the absence of protein aggregate cardiomyopathy in the context of observed arrhythmia in the HSAN-VI model.

Strengths

• Data is recent, with a last updated date of April 2026.
• The research provides specific, controlled experimental conditions such as isoflurane anesthesia.

Limitations

• The dataset is very small, consisting of a single 607.1 KB PDF file with no raw tabular data.
• The sample size (number of mice studied) and specific numerical results are not provided in the metadata.
• Data is presented as a research article summary, limiting direct computational analysis.

Provenance

Source

figshare, authored by Nozomu Yoshioka.

Collection Method

Experimental data from a conditional Dystonin (Dst) gene-trap mouse model, with gene inactivation via Cre recombinase (Advillin-Cre, Vglut2-Cre).

Freshness

Last updated in April 2026.