Adult Mouse Neural Stem Cell Migration Patterns from Hippocampal and Ventricular Niches

A figshare-hosted dataset by Sarnai Amartumur, last updated in June 2026, describing in vitro experiments on adult neural stem cells. The 902.3 KB PDF likely contains quantitative morphological and migration data comparing cells from the hippocampal subgranular zone and ventricular subventricular zone of the mouse brain. The research uses microfluidic and spheroid culture models to characterize niche-associated cellular behaviors and responses to amyloid-β exposure.

Use Cases

• Compare neurite length and motility metrics between SGZ- and SVZ-derived neural stem cells based on the described morphological features.
• Model collective versus dispersed migration patterns in engineered neural cultures based on the described migration behaviors.
• Investigate the effects of oligomeric amyloid-β on spheroid organization and gene expression based on the described neurotoxicity assays.
• Analyze the retention of TUJ1+ and GFAP+ cell populations in bilayer spheroid cultures over time based on the described neural-glia organization.

Strengths

• Data is derived from a controlled in vitro model using microfluidic cultures, as described.
• Includes comparative analysis of two distinct neural stem cell niches (SGZ and SVZ).
• The dataset is associated with a specific experimental protocol involving exposure to oligomeric amyloid-β and gene-expression profiling.

Limitations

• The dataset is small in scale at 902.3 KB, suggesting limited data volume.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data likely gathered from in vitro experiments using microfluidic-based cultures and bilayer spheroids with adult mouse neural stem cells.

Freshness

Last updated 2026-06-03 06:01:59; freshness should be verified.