PilY1 Protein Diversity and Evolution in Myxococcota Bacteria

Sixty-seven representative myxobacterial genomes reveal PilY1 adhesin proteins are widely distributed, with an average of two homologs per genome. The dataset, authored by Utkarsha Mahanta and last updated in May 2026, includes phylogenetic and structural analyses suggesting functional specialization through vertical inheritance and horizontal gene transfer. It reconfirms that pilY1 genes frequently occur in conserved operons with minor pilins, supporting their role in pilus assembly.

Use Cases

• Phylogenetic classification of PilY1 proteins based on domain architecture, protein length, and cysteine content.
• Investigating functional specialization of Type IVa pilus systems based on PilY1 N-terminal domain variation.
• Identifying potential horizontal gene transfer events based on PilY1 clustering patterns across bacterial phyla.
• Structural modeling of protein-protein interactions within minor pilin and PilY1 complexes.
• Comparative genomic analysis of PilY1 gene cluster organization and operon conservation.

Strengths

• Analysis includes sixty-seven representative myxobacterial genomes, providing a broad taxonomic sample.
• Phylogenetic reconstruction identifies several well-supported clades, offering a clear evolutionary framework.
• The dataset is published under a CC-BY-4.0 license, permitting open reuse and modification.

Limitations

• The dataset is a 1.9 MB PDF, likely containing analysis and figures rather than raw, machine-readable data tables.
• Row and column counts are unknown, limiting suitability assessment for direct computational analysis.
• The description lacks specific column-level documentation; data semantics must be inferred from the text.

Provenance

Source

figshare

Collection Method

Genomic, phylogenetic, and structural analysis of publicly available myxobacterial genomes.

Freshness

Last updated 2026-05-07 05:41:14