DNER Drives Glycolytic Reprogramming in Renal Cell Carcinoma

A 2.6 MB research document from figshare, authored by Anrui Li and last updated on 2026-05-22. The study investigates the role of the DNER gene in clear cell renal cell carcinoma (ccRCC), linking it to metabolic reprogramming and immune microenvironment remodeling via the JAK2/STAT3 signaling pathway.

Use Cases

• Study the link between DNER expression and glycolytic flux in cancer cells based on the described mechanistic findings.
• Investigate the role of JAK2/STAT3 signaling in tumor metabolism based on the described protein interaction and pathway activation.
• Explore connections between tumor cell metabolism and macrophage polarization based on the described lactate-driven immunosuppressive microenvironment.
• Assess potential biomarkers for PARP inhibitor sensitivity in ccRCC based on the preliminary evidence linking DNER overexpression to Olaparib.

Strengths

• Document is under a permissive CC-BY-4.0 license, allowing for broad reuse.
• The description provides a detailed, multi-methodological account of the study's aims, methods, and conclusions.

Limitations

• The primary data file is a 2.6 MB DOCX document, not a structured dataset; column-level documentation is absent and field semantics must be inferred.
• Row count and data structure are unknown, which may limit suitability assessment for computational analysis.
• Freshness should be verified as the last update date is in the future (2026-05-22).

Provenance

Source

figshare

Collection Method

Integrated bioinformatic analyses and experimental validation (in vitro and in vivo) as described in the document.

Freshness

Last updated 2026-05-22 06:09:52