Esketamine Adverse Events Meta-Analysis from Nine Randomized Controlled Trials

A systematic review and meta-analysis of nine randomized controlled trials involving 1,449 patients, conducted by Yang Qu and published in 2026. It evaluates the dose-dependent safety profile of esketamine for treatment-resistant depression, comparing adverse event risks across different dosages and geographic regions. The analysis includes data from international and Mainland China studies up to March 2025.

Use Cases

• Assessing dose-response relationships for adverse events based on reported dosage subgroups (28-84 mg nasal spray, 0.20–0.40 mg/kg intravenous).
• Comparing safety profiles across geographic regions based on the subgroup analysis of Mainland China versus International multi-regional studies.
• Evaluating the trade-off between clinical efficacy and tolerability based on the reported response rate (RR=1.94) and discontinuation rate (2.22-fold increase).
• Informing precision dosing strategies for treatment-resistant depression based on the analysis of dose-dependent risk factors.

Strengths

• Includes data from nine randomized controlled trials with 1,449 patients.
• Provides specific dose-response metrics, such as relative risks for nausea (3.72 vs. 1.69) and dissociation (10.65 vs. 3.27) between high and low-dose groups.
• Conducts subgroup analyses by dosage, administration route, and geographic region.

Limitations

• The underlying data tables and column definitions are not provided, requiring inference from the manuscript.
• The dataset is a 12.0 KB document, suggesting it contains summary results rather than raw patient-level data.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

Systematic review of PubMed, Embase, Cochrane Library, CBM, CNKI, and Wanfang databases.

Collection Method

Meta-analysis of randomized controlled trials.

Time Range

Studies from database inception to March 2025.

Freshness

Last updated 2026-05-28 06:23:31.

Geography

International, with subgroup analysis for Mainland China versus International multi-regional studies.