Zoledronic Acid Effects on Femoral Structure and Strength in Growing Rice Rats

Two preclinical studies in female rice rats investigated dose-, duration-, and age-dependent effects of zoledronic acid on femoral bone. The data includes pQCT measurements of bone mineral content, density, area, microstructure, and 3-point bending biomechanical properties. The dataset was authored by J. Ignacio Aguirre and last updated on June 3, 2026.

Use Cases

• Modeling dose-response relationships for zoledronic acid based on reported metaphyseal BMC increases of 15-25%.
• Analyzing the interaction between treatment age and duration on cortical bone parameters and mechanical properties.
• Investigating nonlinear responses in cortical structure and mechanics based on extended treatment durations mentioned in the results.

Strengths

• The dataset is derived from two complementary preclinical studies with controlled dose and duration variables.
• Results include specific quantitative findings, such as oncologic doses producing 15-25% greater increases in metaphyseal BMC than the osteoporosis dose.
• The dataset is licensed under CC-BY-4.0, allowing for open reuse.

Limitations

• The dataset is described in a 17.1 KB DOCX file, which is a very small size suggesting limited raw data.
• Column-level documentation is absent; field semantics must be inferred from the description after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Preclinical animal studies involving pQCT scanning and 3-point bending tests.

Freshness

Last updated 2026-06-03 04:27:20; freshness should be verified.