Mouse Colon T Cell Data in Chronic Chagas Disease

A figshare-hosted research article by Jung-Sun Cho, last updated March 2026, details a study on immune cell populations in the mouse colon during Trypanosoma cruzi infection. The 1.3 MB PDF describes flow cytometry and microscopy results from C57BL/6 mice infected with a transgenic parasite strain, analyzed during acute (~30 days) and chronic (~90 days) phases. Findings focus on the role of double-negative T cells in parasite persistence and gut immunity.

Use Cases

• Study the dynamics of double-negative T cell populations based on flow cytometry data mentioned in the description.
• Investigate the relationship between inflammatory and regulatory T cell phenotypes and parasite burden based on the described experimental model.
• Analyze tissue-specific immune responses in the colon during chronic infection based on the described bioluminescence and microscopy methods.

Strengths

• Data is associated with a specific, peer-reviewed experimental model using C57BL/6 mice and a transgenic T. cruzi strain.
• The description provides quantitative results, such as a ~1.5-fold increase in DN T cells during the acute phase.
• Research is openly shared under a CC-BY-4.0 license, permitting reuse with attribution.

Limitations

• The primary data (e.g., raw flow cytometry files) are not provided; the dataset is a 1.3 MB PDF research article.
• Column-level documentation for any underlying quantitative data is absent; field semantics must be inferred from the text.
• Row count for any potential underlying tabular data is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental data from a laboratory study involving mouse infection, tissue collection, flow cytometry, and microscopy.

Time Range

Experimental phases: acute (~30 days post-infection) and chronic (~90 days post-infection).

Freshness

Last updated 2026-03-18 05:34:33