Data Sheet 1: PRPS2 Role in Non-Small Cell Lung Cancer Tumor Growth

A 214.2 KB document authored by Qian Xu and last updated on May 12, 2026, describes a study on phosphoribosyl pyrophosphate synthetases 2 (PRPS2) in non-small cell lung cancer (NSCLC). The research analyzes PRPS2 expression patterns, validates levels with RT-qPCR, and uses cell line-derived xenograft models to investigate its role in tumor growth via the PI3K/AKT signaling pathway.

Use Cases

• Validate PRPS2 as a biomarker for NSCLC based on its described overexpression in cancer samples.
• Study the relationship between PRPS2 and the PI3K/AKT signaling pathway as described in the research methods.
• Investigate the inhibitory effects of PRPS2 knockdown on tumor growth using the described in vivo model.
• Explore the potential of natural compounds like pristimerin for targeting PRPS2 in cancer therapy.

Strengths

• The study description includes specific experimental methods like RT-qPCR, Western blotting, and in vivo xenograft models.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• The dataset is a 214.2 KB DOCX file, which is a very small document and not a structured data file.
• Row count and column-level documentation are absent; data semantics must be inferred from the text.
• The description is a research summary; the actual underlying numerical or tabular data is not directly accessible.

Provenance

Source

figshare

Collection Method

Research study involving database analysis, cell culture assays, and animal models.

Freshness

Last updated 2026-05-12 05:42:12