Icaritin Effects on Allograft Rejection and Tumor Burden in Mouse Models

A research data sheet describes the dual role of the drug icaritin in mouse models of organ transplantation and cancer. The document, authored by Jinliang Duan and last updated in March 2026, details experimental methods including heart transplantation, single-cell RNA sequencing, and flow cytometry. It reports findings on icaritin's mechanism of action via the CEBPB/PIM1 axis to suppress T-cell activity.

Use Cases

• Analyzing the molecular mechanism of icaritin based on described scRNA-seq and flow cytometry data.
• Studying Th1 cell differentiation suppression based on the described in vitro CD4+ T-cell culture experiments.
• Investigating drug binding interactions based on described molecular docking and dynamics simulations.
• Evaluating combined immunosuppressive and anti-tumor efficacy based on the described tumor-bearing transplantation model.

Strengths

• Document is under a permissive CC-BY-4.0 license for reuse.
• Research methodology is described in detail, including scRNA-seq, flow cytometry, and molecular docking.
• Last updated date is provided (2026-03-18).

Limitations

• The dataset is a 394.4 KB DOCX file, indicating limited scope and likely containing textual descriptions rather than raw experimental data.
• Column-level documentation and sample data are unavailable, making field semantics and structure unknown.
• Row count is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare, author Jinliang Duan.

Collection Method

Experimental research involving mouse models, laboratory assays, and computational simulations.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026-03-18 05:34:52; freshness should be verified.

Geography

Geographic coverage not specified.