Data Sheet 1: N4BP1 Role in Neutrophil–Epithelial Crosstalk in Periodontitis

A research data sheet from figshare, authored by Yuqiang Sun and last updated on 2026-05-28, describes findings on the dual role of the N4BP1 gene in periodontitis. The 16.9 KB document integrates single-cell RNA sequencing and Mendelian randomization analysis to identify a specific neutrophil subset and its interactions with epithelial cells. Key findings were validated using a murine ligature-induced periodontitis model and targeted modulation in human cells.

Use Cases

• Study neutrophil subset heterogeneity in inflammatory disease based on single-cell RNA sequencing analysis described.
• Investigate gene regulatory mechanisms in periodontitis based on Mendelian randomization analysis mentioned.
• Analyze cell-type-specific interactions between immune and epithelial cells based on the described crosstalk mediated by N4BP1.
• Explore potential therapeutic targets for inflammatory diseases based on the identified role of N4BP1 in calibrating pro- and anti-inflammatory signals.

Strengths

• The description provides a detailed methodological background including scRNA-seq and Mendelian randomization.
• Key findings were validated using a murine ligature-induced periodontitis model and human cell experiments.
• The dataset is openly shared under a CC-BY-4.0 license.

Limitations

• The dataset is a 16.9 KB DOCX file, indicating a very limited data scope, likely a summary document rather than raw data.
• Row count and column-level documentation are absent; data structure and semantics must be inferred after download.
• The description metadata is limited to the research background; actual data quality requires manual inspection.

Provenance

Source

figshare, author Yuqiang Sun

Collection Method

Integrated single-cell RNA sequencing and Mendelian randomization analysis, validated with a murine model and human cell modulation.

Freshness

Last updated 2026-05-28 04:54:37; freshness should be verified.