Early Proteomic Signatures of Alzheimer's Disease in Retina and Brain of 3xTg-AD Mice

Proteomic profiling of retina and brain tissue from 4-week-old triple-transgenic Alzheimer's disease mice identified 92 significantly altered proteins in the retina and 130 in the brain. The dataset, authored by Artjola Puja and shared under a CC-BY-4.0 license, was last updated in May 2026. It captures molecular changes prior to detectable retinal structural abnormalities.

Use Cases

• Identify overlapping protein biomarkers between brain and retina based on the eight proteins common to both tissues.
• Analyze early disruptions in mitochondrial function based on described changes in mitochondrial energetics and respiratory chain components.
• Investigate alterations in vision-related pathways based on the reported reduction of vision-related proteins in the retinal proteome.
• Study preclinical changes in intracellular transport and autophagy based on the described protein alterations in vesicular transport and autophagy pathways.

Strengths

• Includes proteomic data from two distinct tissues (retina and brain) for comparative analysis.
• Focuses on a very early disease time point (4-week-old mice) prior to morphological changes.
• Quantifies a specific number of altered proteins: 92 in retina and 130 in brain.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• Data is derived from a specific transgenic mouse model (3xTg-AD), which may not fully recapitulate human disease.

Provenance

Source

figshare, author Artjola Puja.

Collection Method

Quantitative proteomic profiling performed on tissue from triple-transgenic AD (3xTg-AD) mice.

Time Range

Data from 4-week-old mice.

Freshness

Last updated 2026-05-18 05:36:34; freshness should be verified.

Geography

Laboratory study; geographic coverage is not specified.