Sex-Related Transcriptional Differences in CD8+ T Cells During Chronic Viral Infection

Single-cell RNA-sequencing data reveals early transcriptional differences between male and female CD8+ T cells during chronic viral infection. The 4.3 MB PDF file, authored by Nyambura Kahia and last updated in May 2026, shows female T cells exhibit an early exhaustion-like program compared to males. This dataset provides insights into sex differential immune responses.

Use Cases

• Identify sex-biased gene expression patterns in CD8+ T cells based on single-cell RNA-sequencing data.
• Compare early transcriptional programs during chronic versus acute viral infection.
• Investigate the molecular basis of T cell exhaustion development.
• Analyze immunophenotyping data to correlate transcriptional states with cell surface markers.

Strengths

• Data is derived from single-cell RNA-sequencing and immunophenotyping analyses, providing high-resolution molecular profiles.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.
• The description provides a clear biological finding: female CD8+ T cells show an early exhaustion-like program.

Limitations

• The dataset is provided as a 4.3 MB PDF file, which likely contains summarized results rather than raw or processed data tables.
• Column-level documentation and sample data are unavailable, making direct computational analysis difficult.
• The row count and specific data structure are unknown, limiting suitability assessment for machine learning.

Provenance

Source

figshare

Collection Method

Single-cell RNA-sequencing and immunophenotyping analyses performed in vivo.

Freshness

Last updated 2026-05-12 05:42:47.