Gut Microbiome and Mycobiome in Ulcerative Colitis Across Pediatric and Adult Patients

Targeted metagenomic data from 73 bacterial and 69 fungal samples collected from 26 pediatric and 47 adult patients with ulcerative colitis. The dataset was created by Francesca Toto and last updated on 2026-04-28. It includes microbial diversity metrics, mucosal immune markers, and clinical variables to investigate age-related ecological patterns.

Use Cases

• Compare fungal versus bacterial community richness across life stages based on the described alpha- and beta-diversity analyses.
• Identify age-associated fungal taxa like Saccharomycetes or Clavispora based on the enrichment and depletion patterns mentioned.
• Investigate correlations between immune markers (lysozyme, sIgA) and microbial abundance (e.g., Faecalibacterium prausnitzii) as described in the results.
• Model the relationship between clinical variables (disease activity, duration, treatment) and microbial dysbiosis, particularly in the young adult subgroup highlighted.

Strengths

• Includes paired bacterial (73 samples) and fungal (69 samples) targeted metagenomes from a defined cohort of 73 patients.
• Integrates microbial data with clinical variables (disease activity, duration, treatment) and mucosal immune markers assessed by ELISA.
• Explicitly stratifies analysis by life stage (pediatric vs. adult), identifying a distinct young adult subgroup with pronounced dysbiosis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (401.8 KB), indicating limited scope, likely containing summary or processed results rather than raw sequencing reads.

Provenance

Source

Francesca Toto via figshare.

Collection Method

Targeted metagenomic sequencing of gut bacteria and fungi from patient samples, with subsequent bioinformatic and statistical analysis.

Freshness

Last updated 2026-04-28 05:28:23; freshness should be verified.