Pomegranate Extract and TMAO Response in Healthy Adults: A Randomized Crossover Trial

34 healthy, omnivorous adults participated in a two-phase dietary intervention study investigating the effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide (TMAO) levels following an oral carnitine challenge. The dataset includes blood, urine, and stool sample measurements from an 18-day double-blind, randomized, placebo-controlled, crossover study involving 20 high TMAO producers. The data was collected by Julia E. Haarhuis and shared under a CC-BY-4.0 license, with a last update recorded on 2026-05-20.

Use Cases

• Analyzing the pharmacokinetic response of TMAO following an oral carnitine challenge based on area under the curve (AUC) measurements.
• Investigating potential sex- and age-dependent effects of a polyphenol intervention on metabolite levels based on post hoc subgroup analyses mentioned.
• Studying the proportion of high TMAO producers in a healthy adult cohort based on the reported 91% rate from Phase I.
• Modeling the impact of standardized dietary conditions on clinical trial outcomes based on the described controlled run-in diet and meal provision.

Strengths

• Data originates from a tightly controlled clinical trial with standardized meals and a low-TMAO precursor run-in diet to minimize dietary variability.
• Includes measurements from multiple sample types (blood, urine, stool) quantified using LC-MS/MS, a specific analytical method.
• Study design features a double-blind, randomized, placebo-controlled, crossover methodology with a 10-day washout period.

Limitations

• Row count is unknown, which may limit suitability assessment for certain analyses.
• Column-level documentation is absent; field semantics must be inferred after download from the PDF.
• The dataset is small in scale (503.0 KB), indicating limited data volume.

Provenance

Source

Julia E. Haarhuis via figshare.

Collection Method

Data collected from a randomized controlled crossover clinical trial (NCT06518343).

Freshness

Last updated 2026-05-20 05:44:11; freshness should be verified.