Effect of Biofilm on Tigecycline Activity Against Mycobacterium Abscessus

Dynamic time-kill assays in a hollow fiber system mimicked tigecycline lung exposure under diverse intrapulmonary aerosol administration scenarios. The study by Hyunseo Park, last updated in April 2026, integrates data from in vitro assays and biofilm permeability studies into a PK/PD model. This model captures factors like dose-dependent bacterial killing and biofilm-associated changes in permeability that influence antibacterial activity.

Use Cases

• Modeling antibiotic exposure-response relationships based on dynamic time-kill assay data
• Simulating the barrier effect of biofilms on drug permeability based on Transwell study results
• Predicting bacterial resistance development patterns under different dosing regimens
• Quantifying the impact of biofilm formation on antibacterial efficacy using integrated PK/PD modeling

Strengths

• Data is integrated from multiple experimental systems: hollow fiber infection model and Transwell permeability studies.
• The PK/PD model described captures multiple factors including biofilm formation and resistance development.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is a 729.4 KB PDF file; underlying raw data tables are not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the PDF.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

figshare

Collection Method

Experimental data from in vitro dynamic time-kill assays and biofilm permeability studies, integrated via PK/PD modeling.

Freshness

Last updated 2026-04-28 05:28:09