Assisted Reproductive Technology Outcomes for Chromosome 9 Inversion

A retrospective cohort study from September 2008 to December 2023 analyzed 40,502 ART cycles, comparing outcomes for 903 couples with pericentric inversion of chromosome 9 against 39,599 couples with normal karyotypes. The study used propensity score matching to evaluate live birth rate, pregnancy, miscarriage, and neonatal outcomes.

Use Cases

• Compare live birth rate (LBR) outcomes between inv(9) and normal karyotype groups using propensity score-matched cohorts.
• Analyze secondary outcomes like biochemical pregnancy, clinical pregnancy, and miscarriage rates across the matched groups.
• Investigate cycle parameters including oocyte yield, fertilization rate, and blastocyst formation rate for inv(9) carriers.
• Examine neonatal outcomes such as multiple births and low birth weight among live births in the study population.

Strengths

• Large-scale study covering 40,502 ART cycles over a 15-year period from 2008 to 2023.
• Includes a specific cohort of 903 cycles involving couples with the chromosome 9 inversion.
• Employs rigorous statistical methodology using propensity score matching to balance baseline characteristics.

Limitations

• Dataset is presented as a 51.2 KB DOCX file, indicating a summary document rather than raw, analyzable tabular data.
• Specific column definitions, row counts for individual variables, and sample data are unavailable for direct computational analysis.
• Retrospective study design may have inherent limitations compared to a prospective or randomized trial.

Provenance

Source

figshare, authored by Wenjie Huang.

Collection Method

Retrospective cohort study of medical records.

Time Range

September 2008 to December 2023.

Freshness

2026-03-26

Geography

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