Systematic Review and Meta-Analysis on Ventilation Modes for Weaning Critically Ill Adults

A systematic review and meta-analysis document comparing proportional assist ventilation plus (PAV+) with pressure support ventilation (PSV) for weaning critically ill adults from mechanical ventilation. The document synthesizes results from 7 randomized controlled trials involving 1,214 patients, published by Yifei Wang in March 2026. It includes trial sequential analysis and subgroup analyses to assess outcomes like weaning success, reintubation, and mortality.

Use Cases

• Conducting secondary analysis of weaning success rates based on the reported risk ratios and confidence intervals.
• Informing clinical guideline development based on the synthesized evidence from multiple RCTs.
• Designing future clinical trials based on the identified gaps and subgroup analyses (e.g., spontaneous breathing trial vs. continuous weaning).
• Teaching evidence-based medicine principles using a documented meta-analysis and trial sequential analysis.

Strengths

• Includes trial sequential analysis to enhance the robustness of statistical findings.
• Synthesizes data from 7 randomized controlled trials with a total of 1,214 patients.
• Registered with PROSPERO (CRD420251170692), indicating a predefined protocol.
• Released under a CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The primary data file is a 14.7 KB DOCX document, indicating a limited scope focused on the review manuscript rather than raw trial data.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the text.
• Row count for any potential supplementary data is unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare, authored by Yifei Wang.

Collection Method

Systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials sourced from databases like CENTRAL, PubMed, and Embase.

Time Range

Literature search from database inception to October 1, 2025.

Freshness

Last updated 2026-03-17 13:06:16.

Geography

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