Molecular Dynamics Study of H2BE76K Mutation Effects on Nucleosome Stability

A molecular dynamics simulation study investigates the structural and dynamic effects of the cancer-associated H2BE76K mutation on nucleosomes. The 8.2 MB PDF, authored by Valentina Migliorati and last updated in May 2026, compares wild-type and mutant nucleosome forms. It details how the mutation disrupts local hydrogen bonding, leading to long-range conformational changes and altered DNA-histone interactions.

Use Cases

• Modeling nucleosome stability changes based on oncohistone mutations described in the study
• Analyzing the propagation of local structural perturbations to long-range dynamics as detailed in the description
• Studying the mechanistic link between histone mutations and altered DNA contact flexibility mentioned in the text

Strengths

• The study provides a detailed mechanistic explanation of mutation effects, as described in the abstract.
• The dataset is openly licensed under CC-BY-4.0 for reuse.

Limitations

• The primary data format is a PDF (8.2 MB), which may require extraction for computational analysis.
• Row count and column-level documentation are absent; data structure must be inferred from the paper.
• The dataset is small in scale (8.2 MB), limiting the volume of raw simulation data available.

Provenance

Source

figshare

Collection Method

Molecular Dynamics simulations performed by the author.

Freshness

Last updated 2026-05-13 05:50:55